ASLAN Pharmaceuticals to Present New Data on Varlitinib at European Society for Medical Oncology Congress
SINGAPORE, July 31, 2019 (GLOBE NEWSWIRE) -- ASLAN Pharmaceuticals (Nasdaq:ASLN, TPEx:6497), a clinical-stage oncology and immunology focused biopharma company, today announced that an abstract on varlitinib has been accepted for poster presentation at the upcoming 2019 European Society for Medical Oncology (ESMO) Congress in Barcelona, Spain on 27 September - 1 October 2019.
The abstract accepted for poster presentation (Abstract #1311), titled “A phase I study of varlitinib (VAR; ASLAN001) an oral pan-HER tyrosine kinase inhibitor (TKI) combined with mFOLFIRI chemotherapy in advanced solid tumors” will be presented by Dr. Aaron Tan.
Varlitinib is a highly potent pan-HER inhibitor that targets the human epidermal growth factor receptors HER1, HER2 and HER4. At ESMO, new data will be presented from a phase 1 study to determine the safety and maximum tolerated dose (MTD) of varlitinib in combination with modified irinotecan and infusional 5-fluorouracil (mFOLFIRI) up to 9 cycles followed by varlitinib monotherapy in advanced solid tumours. The investigator-initiated trial was conducted by Dr. Matthew Chau Hsien Ng and supported by ASLAN and the Singapore National Medical Research Council.
The abstract will be available online at https://www.esmo.org/ on 23 September, 00:05 CEST.
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About varlitinib (ASLAN001)
Varlitinib (ASLAN001) is a highly potent, oral, reversible, small molecule pan-HER inhibitor that targets the human epidermal growth factor receptors HER1, HER2 and HER4. These receptors can be mutated or overexpressed in many tumours, which can cause excessive proliferative activity and uncontrolled growth. Therefore, by inhibiting the activation of the HER receptors, varlitinib could inhibit proliferation and control tumour growth. Varlitinib has been granted orphan drug designation in the United States for gastric cancer and cholangiocarcinoma, a sub-type of biliary tract cancer, and was awarded orphan drug designation for the treatment of biliary tract cancer by the Ministry of Food and Drug Safety in South Korea.
About ASLAN Pharmaceuticals
ASLAN Pharmaceuticals (Nasdaq:ASLN, TPEx:6497) is a clinical-stage oncology and immunology focused biopharma company targeting cancers that are both highly prevalent in Asia and orphan indications in the United States and Europe. Led by a senior management team with extensive experience in global and regional development and commercialisation, ASLAN is headquartered in Singapore and has offices in Taiwan and China. ASLAN’s clinical portfolio is comprised of three product candidates which target validated growth pathways applied to new patient segments, novel immune checkpoints and novel cancer metabolic pathways. ASLAN’s partners include Array BioPharma, Bristol-Myers Squibb, Almirall and CSL. For additional information please visit www.aslanpharma.com.
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