Tom Brady had Peyton Manning's number once again in a 31-21 win. Brady improved to 9-4 lifetime against Manning after his first win against his future fellow Hall of Famer with Manning quarterbacking the Denver Broncos. Brady completed 23 of 31 while directing four long TD drives. The Patriots rushed for 252 yards, including Stevan Ridley gaining a career-best 151.
Manning had a fine day statistically. He was 31 of 44 for 345 yards and three TDs. But he lost a fumble on a third-quarter sack as Denver fell to 2-3. The Pats are 3-2.
Move over, Johnny U. Here comes Drew Brees.
The New Orleans signal-caller broke the NFL record by throwing touchdown passes in 48 straight games. Brees threw for four scores as the Saints registered their firs twin of the season, 31-24 over the San Diego Chargers. Brees finished 29-for-45 for 370 yards and four TDs.
The record had been set by Johnny Unitas with the Baltimore Colts more than a half-century ago. No one had come within 10 games of the record until Brees began to close in late last season. Tom Brady has the third-longest streak, extending his to 37 games Sunday in a victory over Denver.
Coach Sean Payton, assistant head coach Joe Vitt and general manager Mickey Loomis -- all three suspended in the NFL's bounty investigation -- were permitted by the NFL at Brees' request to attend the game.
Unitas' son, Joe, also was present. Before the game, Joe had said that his father always said that records were made to be broken and that his father would have enjoyed watching a player like Brees set the record.
The Falcons preserve their status as one of the NFL's two unbeaten teams with a hard-fought 24-17 victory at Washington. The 4-0 Houston Texans are at the New York Jets on Monday night.
Michael Turner's 13-yard touchdown run with 2:46 to play snapped a 17-all tie, helping Atlanta get to 5-0 for the first time in franchise history.
The Redskins eighth straight home loss leaves them with a 2-3 record.
Winning quarterback Matt Ryan made good on 34 of 52 pass attempts for 345 yards. Tight end Tony Gonzalez caught 13 passes for 123 yards and a touchdown.
Redskins signal caller Robert Griffin III left the game early in the third quarter after being hit in the head and didn't return. The No. 2 pick in this year's draft was replaced by fourth-round pick Kirk Cousins who threw a 77-yard touchdown pass to Santana Moss to give Washington a fourth-quarter lead. But Cousins also threw two interceptions in the final two minutes.
Redskins coach Mike Shannahan says Griffin suffered a "mild concussion" and will be evaluated again on Monday.
Playing just days after it was announced that first-year head coach Chuck Pagano was hospitalized and being treated for leukemia, the Colts responded with a gutsy 30-27 victory over the visiting Packers.
Andrew Luck and Reggie Wayne hooked up on a 4-yard scoring pass with 35 seconds on the clock to lift Indianapolis to its second straight win after an 0-2 start.
It was the No. 1 draft pick's third scoring toss of the day, all of them coming after the Colts trailed 21-3 at the half. Luck completed 31 of 55 passes for 362 yards and was picked off once.
Green Bay had a chance to force overtime, but Mason Crosby missed a 51-yard field goal with 3 seconds to go.
Adam Vinatieri (vin-uh-TEHR'-ee) booted three field goals for the winners, including one from 50 yards out.
Packers quarterback Aaron Rodgers was 21 of 33 for 243 yards and three scores. He also threw one interception as Green Bay drops to 2-3.
Baltimore managed to beat Kansas City 9-6 on a day in which neither starting quarterback played up to par.
The Chiefs Matt Cassel (KAS'-uhl) threw for just 92 yards, was intercepted twice and lost two fumbles before being knocked out of the game in the fourth quarter with what the team describes as a head injury.
Brady Quinn entered and led Kansas City to a second field goal by Ryan Succop (SHUK'-uhp), but the Chiefs defense couldn't get the ball back and Baltimore ran out the clock.
Ravens quarterback Joe Flacco (FLA'-koh) threw for 187 yards and was picked off once.
Justin Tucker made good on all three of his field goal attempts and teammate Ray Rice rushed for 101 yards as Baltimore improves to 4-1. Kansas City is 1-4.
The New York Giants spotted Cleveland a 14-0 lead before storming back to beat the Browns 41-27.
Victor Cruz caught three touchdown passes from Eli Manning while Ahmad Bradshaw surpassed his yardage on the ground for the season with a career-high 200. The Giants are 9-0 in games he has rushed for 100 yards or more.
New York's defense forced three turnovers while helping the Super Bowl champions get to 3-2 on the season.
The Browns were flagged ten times while losing for the 11th straight time dating to last season. They are 0-5 for the first time since their return season to the NFL in 1999.
Pittsburgh has bragging rights in Pennsylvania after beating visiting Philadelphia 16-14 on Shaun Suisham's 34-yard field goal as time expired.
The Eagles took the lead on a 2-yard touchdown pass from Michael Vick to Brent Celek with 6:33 remaining. But Steelers quarterback Ben Roethlisberger (RAWTH'-lihs-bur-gur) engineered a 64-yard drive on Pittsburgh's next possession, leading to the game-winning kick.
Pittsburgh's Rashard Mendenhall ran for 81 yards and a touchdown in his first game of the season after recovering from surgery on a torn ACL in his right knee.
Vick completed 20 of 30 passes for 175 yards and two scores but fumbled twice for the 3-2 Eagles.
The Steelers avoided losing back-to-back games for the first time in three years and improve to 2-2.
After suffering back-to-back overtime losses, the visiting Dolphins hung on to beat the Bengals 17-14.
Cincinnati got the ball at its 20 following a punt with 1:45 to go, but Andy Dalton's second interception sealed Miami's second win in five games this season.
Dalton was also sacked three times while completing 26 of 43 passes for 234 yards.
Miami rookie Ryan Tannehill finished 17 of 26 for 223 yards without a pick.
The Bengals fall to 3-2.
The San Francisco 49ers dominated Buffalo 45-3 as the Niners racked up a franchise-record 621 total yards. Alex Smith tossed three TD passes and threw for 303 yards. Receivers Michael Crabtree and Vernon Davis each went over 100 yards in receptions. Frank Gore ran for 106 yards and a score.
San Francisco's defense wasn't bad either. The Niners held Buffalo to just 89 yards rushing and Bills QB Ryan Fitzpatrick could throw for just 126 yards and tossed an interception.
Minnesota torched Tennessee 30-7. Percy Harvin caught eight passes for 108 yards and one TD. Christian Ponder threw his first two interceptions after 143 attempts without one, but he still finished 25 for 35 for 258 yards and two scores against the reeling Titans, who fell to 1-4. The Vikings are 4-1.
Seattle rookie QB Russell Wilson outplayed Carolina QB Cam Newton and the Seahawks engineering a 16-12 road victory over the 1-4 Panthers. Wilson hit Golden Tate with a 13-yard TD strike late in the third quarter. Wilson threw for 221 yards, while Marshawn Lynch ran for 85 yards for the 3-1 Seahawks.
Newton threw for 141 yards on 12-for-29 passing, while the Panthers managed just 190 total yards against the stout Seahawks defense.
These end zone celebrations are getting to be routine for Chicago defensive backs Charles Tillman and Lance Briggs. They both returned interceptions for a touchdown -- their second in six days -- in the Bears' 41-3 rout of Jacksonville. The 4-1 Bears scored 38 unanswered points, and they're doing that largely because of their suffocating defense.
Chicago has returned five interceptions for touchdowns in the last three weeks. Tillman and Briggs returned two of the team's five interceptions for touchdowns in Monday night's lopsided with over Dallas. It was the first time since 1950 that Chicago returned interceptions for touchdowns in three consecutive games.