The resurgent Saints shot down the Falcons' chance for an undefeated season.
Drew Brees threw for 298 yards and three scores to lead New Orleans to a 31-27 victory over division-rival Atlanta. Tight end Jimmy Graham caught seven balls for a career-best 146 yards and two TDs.
Atlanta's Matt Ryan racked up 411 yards through the air and had three TD tosses. His tight end, Tony Gonzalez, had 11 receptions for 122 yards and a pair of touchdowns.
The Saints are working their way back into the playoff picture. New Orleans has won four of five following an 0-4 start.
The NFC South-leading Falcons are 8-1.
Peyton Manning made sure John Fox's return to Carolina was a successful one. The Broncos quarterback threw for 301 yards and a touchdown to lead Denver to a 36-14 win over the Panthers. It was the four-time league MVP's 420th touchdown pass, moving him into a tie for second place on the all-time list with Hall of Famer Dan Marino. Brett Favre is the record-holder with 508.
Trindon Holliday returned a punt 76 yards for a touchdown to help the Broncos win for the fifth time in six weeks. They are 6-3 on the season.
The Broncos defense sacked Cam Newton seven times, including once for a safety. And Tony Carter returned a Newton interception 40 yards for a score.
Fox coached the Panthers for nine seasons. He downplayed his return all week, but celebrated with a few fist pumps after the victory.
The Giants looked anything but the defending Super Bowl champions for a second straight week.
Andy Dalton threw a career-high four touchdown passes to four different receivers and Cincinnati snapped a four-game losing streak by whacking visiting New York 31-13.
The Bengals took advantage of a fumble and Eli Manning's two interceptions, which set up third-quarter touchdowns. The win gets them to 4-5 on the season.
The Giants head into their bye with back-to-back losses and a lot of issues, especially on offense. Manning had another subpar game, failing to live up his family legacy of beating the Bengals. Older brother Peyton improved to 8-0 against Cincinnati on the same field a week earlier, leading Denver to a 31-23 win.
The Giants turned it over four times in the second half.
Andy Reid's nightmare season in Philadelphia continues. After a 3-1 start, the Eagles suffered their fifth straight loss, 38-23 at Dallas. Tony Romo tossed two TDs. The Cowboys defense and special teams scored two touchdowns. Dwayne Harris had a 78-yard punt return for a score and Brandon Carr returned an interception 47 yards. To make matters worse, Eagles QB Michael Vick suffered a concussion in the first half.
Nick Foles filled in for Vick and briefly rallied the Eagles until the Cowboys started showing some touchdown versatility. Romo hit Dez Bryant on a 30-yard pass on the final play of the third quarter, and Harris and Carr scored their TDs in the fourth quarter.
After a slow start, the Cowboys are 4-5, just a game and a-half back of the NFC East-leading Giants.
The Seattle Seahawks routed the New York Jets 28-7 behind a pair of TD passes by rookie Russell Wilson. The Seahawks are 6-4. Meanwhile, the Jets fell to 3-6, their worst start since 2007.
Mark Sanchez struggled in his reunion with Seattle coach Pete Carroll, his former coach at USC. Sanchez threw a costly interception at the goal line in the first half, then fumbled at the Seattle 32.
Muhammad Wilkerson's fumble return for a TD was the only score for New York. That kind of offensive ineptitude is almost certain to wake up the chorus of "Let's play Tim Tebow" among the armchair quarterbacks in the Big Apple.
The Ravens scored on six of their first seven possessions and set a club record for points in a 55-20 rout of the visiting Oakland Raiders.
Joe Flacco threw for 341 yards and three touchdowns while helping AFC North leader Baltimore improve to 7-2. Torrey Smith caught two of the scoring passes. Teammate Jacoby Jones returned a kickoff 105 yards for a score.
It's the first time in three games that Baltimore's defense held an opponent under 40 points.
The 55 points ties an Oakland record for points allowed.
The Vikings rode the legs of the NFL's leading rusher to a 34-24 victory over the visiting Detroit Lions. Adrian Peterson ran for 171 yards on 27 carries.
Peterson, who underwent reconstructive surgery on his left knee just 10 1/2 months ago, gained 120 of those yards in the final 15 minutes. His 61-yard scoring romp midway through the fourth quarter sealed Minnesota's sixth win in 10 outings this season.
Lions receiver Calvin Johnson caught 12 passes for 207 yards and a TD, but it wasn't enough to keep Detroit from falling to 4-5.
The New England Patriots kept the surprisingly tough Bills winless at Gillette Stadium with a 37-31 victory.
Tom Brady threw for two touchdowns and Devin McCourty ended Buffalo's hopes with a late interception in the end zone.
The AFC East-leading Patriots are 6-3. The last-place Bills are 3-6.
New England is 11-0 against the Bills at Gillette since it opened in 2002 and 20-2 overall in its last 22 games against Buffalo.
The Titans rebounded from last week's 51-20 loss at the hands of the Bears with a 37-3 rout of the Dolphins in Miami.
Team owner Bud Adams put the organization on notice following the loss to Chicago and it seems to have worked. Tennessee shored up its leaky defense that was on pace to set a league record for points allowed in a season. The Titans were credited with four takeaways, including Colin McCarthy's 49-yard interception return for a touchdown. It was one of three picks thrown by Ryan Tannehill.
Tennessee improves to 4-6. Miami's most-lopsided home loss since 1968 drops them to 4-5.
The surging Buccaneers got TDs on offense, defense and special teams while beating visiting San Diego 34-24.
Josh Freeman continues to shine, throwing a pair of scoring passes in Tampa Bay's third straight victory. The Bucs quarterback has thrown for 13 TDs with just one interception in his past five games.
Adam Heyward returned a blocked punt 29 yards for a score and Leonard Johnson took an interception 83 yards to the house.
Tampa Bay is 5-4 following a 1-3 start. San Diego falls to 4-5.
And there's been the first tie in the NFL since 2008. San Francisco and St. Louis played to a 24-all draw at Candlestick Park. Both team's kickers missed overtime field goals.
St. Louis rookie Greg Zuerlein kicked a 53-yarder, but the Rams were penalized 5 yards for delay of game. He tried again from 58 as coach Jeff Fisher played for the win, and missed wide right with 2:42 left in OT.
San Francisco's David Akers missed wide left on a 41-yard attempt that could have sealed it for the NFC West-leading 49ers (6-2-1), who lost quarterback Alex Smith to a first-half concussion.